12/2/2023 0 Comments Roche machinesWhen they compared the tests at a known reference PSA of 1.5 (see page 9) the Abbott Architect read it as slightly under 1.5 whereas the Immulite 2nd generation read it at 2 (!) and the Immulite 3rd generation read it at 1.7. The UK government did a comparision of PSA assays in order to make good purchasing decisions in Feb 2010 and the results were published at this website. However as you can see that these two tests are giving us consistantly different results and I am trying to work out what's happening. Both tests are I believe calibrated to the WHO standard. The tests are done with my husband going at 7am to one collection centre and then at 7:30 to the next on the same day.īoth are ultrasensitive tests - Lab 1 (Prince Alfred) uses the Immulite 2000 3rd gen whereas Lab 2 (Douglas Hanly Moir) uses Abbott Architect. We use 2 labs now and they use different assays. It is not the best, but just one I could find quickly that provides some more detail: Otherwise, you may think your psa is going up - or down - when it reality you are just being fooled by the lack of standardization among different assays. The key, in my view, is to pick one lab and one assay and STICK WITH IT for all of your psa tests. In my opinion (and you should probably take my opinion with a grain of salt because I am not a doctor and am not educated in the sciences), this is one of the most important commonly overlooked issues in psa testing. (But it gets more complicated than that because some WHO-calibrated tests appear to perform more like Hybritech calibrated assays). The bottom line is: one assay is not "better" or "more trustworthy" than the other, but the differences among them can be material - particularly between those calibrated to the Hybritech standard and those calibrated to the WHO standard. I will see if I can dig up the best of the articles, if you are interested. I did extensive reading on the differences among assays a year or so ago.
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